#denotes the equal contribution; * denotes the corresponding author. Full publication list
Nanostructured Electrochemical Biosensor for Real-Time Bioanalysis
Kesler, V.#; Fu, K.#*; Chen, Y.; Park, C.H.; Eisenstein, M.; Murmann, B.; Soh, H.T.* “Tailoring electrode surface charge to achieve discrimination and quantification of chemically similar small molecules with electrochemical aptamers,” Advanced Functional Materials, 2023, 33, 2208534.
Seo, J.-W.#; Fu, K.#. Correa, S.; Eisenstein, M.; Appel, E.A.*; Soh, H.T.* “Real-Time Monitoring of Drug Pharmacokinetics within Tumor Tissue in Live Animals,” Science Advances, 2022, 8, abk2901.
Fu, K.#; Seo, J.-W.#; Kesler, V.#; Maganzini, N.; Wilson, B.D.; Eisenstein, M.; Murmann, B.; Soh, H.T.* “Accelerated Electron Transfer in Nanostructured Electrodes Improves the Sensitivity of Electrochemical Biosensors,” Advanced Science, 2021, 8, 202102495.
Nanopore Electrode Array as High-Performance Electrochemical Sensor
Kwon, S.-R.; Baek, S.; Fu, K.; Bohn, P. W.* “Electrowetting-Mediated Transport to Produce Electrochemical Transistor Action in Nanopore Electrode Arrays,” Small, 2020, 16, 1907249.
Fu, K.; Kwon, S.-R.; Han, D.; Bohn, P. W.* “Single Entity Electrochemistry in Nanopore Electrode Arrays: Ion Transport Meets Electron Transfer in a Confined Geometries,” Accounts of Chemical Research, 2020, 53, 719-728.
Kwon, S.-R.#; Fu, K.#; Han, D.; Bohn, P. W.* “Redox Cycling in Individually Encapsulated Attoliter-Volume Nanopores,” ACS Nano, 2018, 12, 12923-12931.
Fu, K.#; Han, D.#; Crouch, M. G.; Kwon, S.-R.; Bohn, P. W.* “Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays,” Small, 2018, 14, 1703248.
Fu, K.; Bohn, P. W.* “Nanopore Electrochemistry: A Nexus for Molecular Control of Electron Transfer Reactions,” ACS Central Science, 2018, 4, 20-29.
Han, D.; Crouch, M.G.; Fu, K.; Bohn, P. W.* “Correlated Optical and Electrochemical Detection Reveals the Single-Molecule Insights in Zero-Dimensional Nanopore Electrode Arrays,” Chemical Science, 2017, 8, 5345-5355.
Fu, K.; Han, D.; Ma, C.; Bohn, P. W.* “Ion Selective Redox Cycling in Zero-dimensional Nanopore Electrode Arrays at Low Ionic Strength,” Nanoscale, 2017, 9, 5164-5171.
Han, D.; Zaino, L. P.; Fu, K.; Bohn, P. W.* “Redox cycling in Nanopore-Confined Recessed Dual Ring Electrode Arrays,” Journal of Physical Chemistry C, 2016, 120, 20634-20641.
Fu, K.; Han, D.; Ma, C.; Bohn, P. W.* “Electrochemistry at Single Molecule Occupancy in Nanopore-Confined Recessed Ring Disk Electrode Arrays,” Faraday Discussions, 2016, 193, 51-64.
Stimulus-Responsive Polymer for in situ Chemical Sensing and Biosensing
Baek, S.#; Kwon, S.-R.#; Fu, K.; Bohn, P. W.* “Ion Gating in Nanopore Electrode Arrays with Hierarchically Organized pH-Responsive Block Copolymer Membranes,” ACS Applied Materials & Interfaces, 2020, 12,55116-55124.
Fu, K.; Kwon, S.-R.; Han, D.; Bohn, P. W.* “Asymmetric Nafion-Coated Nanopore Electrode Arrays as Redox-Cycling-Based Electrochemical Diodes,” ACS Nano, 2018, 12, 9177-9185.
Fu, K.; Bohn, P. W.* “Nanochannel Arrays for Molecular Sieving and Electrochemical Analysis by Nanosphere Lithography Templated Graphoepitaxy of Block Copolymers,” ACS Applied Materials & Interfaces, 2017, 9, 24908-24916.
Yao, Y.; Fu, K.; Huang, X.; Chen, D. “Polydiacetylene-Tb3+ Nanosheets of Which Both the Color and the Fluorescence Can Be Reversibly Switched between Two Colors,” Chinese Journal of Chemistry, 2017, 35, 1678-1686.
Luo, J.; Fu, K.; Dong, H.; Chen, D. “Self-suspended Pure Polydiacetylene Nanoparticles with Selective Response to Lysine and Arginine,” Chinese Journal of Chemical Physics, 2016, 29, 749-753.
Guo, J.#; Fu, K.#; Zhang, Z.; Yang, L.; Huang Y-C.; Huang C-I.; Zhu L.; Chen, D. “Reversible Thermochromism via Hydrogen-bonded Cocrystals of Polydiacetylene and Melamine,” Polymer, 2016, 105, 440-448.
Fu, K.; Chen, D.* “Nanocomposites of Polydiacetylene and Rare Earth Ions with Reversible Thermochromism,” Chinese Journal of Chemical Physics, 2014, 27, 465-470.
Electrochemical and Optical Measurements for Multiscale and Multimodal Biodetection
Wang, J.#; Soto, F.#; Ma, P.; Ahmed, R.; Yang, H.; Chen, S.; Wang, J.; Liu, C.; Akin, D.; Fu, K.; Cao, X.; Chen, P.; Hsu, E.-C.; Soh, H.T.; Stoyanova, T.; Demirci, U.* “Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots,” ACS Nano, 2022, 16, 10219-10230.
Jia, J.#, Kwon, S.-R.#; Baek, S.; Sundaresan, V.; Cao, T.; Cutri, A.R.; Fu, K.; Roberts, B.; Shrout, J. D.; Bohn, P. W.* “Actively Controllable Solid Phase Microextraction in a Hierarchically Organized Block Copolymer-Nanopore Electrode Array Sensor for Charge-Selective Detection of Metabolites in Biofilms,” Analytical Chemistry, 2021, 93, 14481-14488.
Jia, J.#; Ellis, J. F.#; Cao, T.; Fu, K.; Morales-Sota, N.; Shrount, J. D. Sweedler, J. V.; Bohn, P. W.* “Biopolymer Patterning-Directed Secretion in Mucoid and Non-Mucoid Strains of Pseudomonas aeruginosa Revealed by Multimodal Chemical Imaging,” ACS Infectious Diseases, 2021, 7, 598-607.
Wang, J.; Ahmed, R.; Zeng, Y.; Fu, K.; Soto, F.; Sinclair, B.; Soh, H.T.; Demirci, U.* “Engineering the Interaction Dynamics between Nano-topographically Immunocyte-Templated Micromotors across Scales from Ions to Cells,” Small, 2020, 16, 2005185.
Do, H.; Kwon, S.-R.; Fu, K.; Morales-Soto, N.; Shrout, J. D.; Bohn, P. W.* “Electrochemical Surface-Enhanced Raman Spectroscopy of Pyocyanin Secreted by Pseudomonas aeruginosa Communities,” Langmuir, 2019, 35, 7043-7049.
Crouch, M.G.; Oh, C.; Fu, K.; Bohn, P. W.* “Tunable Optical Metamaterial-Based Sensors Enabled by Closed Bipolar Electrochemistry,” Analyst, 2019, 144, 6240-6246.
Ma, C.#; Fu, K.#; Trujillo, M. J.; Gu, X.; Baig, N.; Bohn, P. W.; Camden, J. P.* “In-situ Probing of Laser Annealing of Plasmonic Substrates with Surface-Enhanced Raman Spectroscopy,” Journal of Physical Chemistry C, 2018, 122, 11031-11037.
Hu, J.; Fu, K.; Bohn, P. W.* “Whole-Cell Pseudomonas aeruginosa Localized Surface Plasmon Resonance Aptasensor,” Analytical Chemistry, 2018, 90, 2326-2332.
Xu, W.#; Fu, K.#; Bohn, P. W.* “Electrochromic Sensor for Multiple Detection of Metabolites Enabled by Closed Bipolar Electrode Coupling,” ACS Sensors, 2017, 2, 1020-1026.
Xu, W.; Fu, K.; Ma, C.; Bohn, P. W.* “Closed Bipolar Electrode-enabled Dual Electrochromic Detectors for Chemical Sensing,” Analyst, 2016, 141, 6018-6024.
Bohn, P. W.; Xu, W.; Fu, K.; Ma, C.; “Bipolar Electrode-Enabled Dual-cell Detectors for Electrochromic Sensing,” US Patent, US10908094.
Fu, K.; Xu, W.; Hu, J.; Lopez, A.; Bohn, P. W.; “Microscale and Nanoscale Electrophotonic Diagnostic Devices,” Bioelectronic Medicine, 2018, Cold Spring Harbor Laboratory Press, DOI: 10.1101/cshperspect.a034249.
Monitoring of intra-tumoral drug pharmacokinetics in vivo with implantable sensors (Stanford eWear Research Highlights)
Nanostructured electrodes improve sensor sensitivity with faster electron transfer (Stanford eWear Research Highlights)
Engineering the interaction dynamics between nano‐topographical immunocyte‐templated micromotors across scales from ions to cells (Stanford eWear newsletter)
Designing Across the Micro-Nano Boundary: Hierarchically Organized Nafion-Nanopore Structures Enable Electrochemical Diodes (Advances in Engineering)
Smallest-scale work in electrochemistry leads to sizable research strides (Notre Dame Research)
Closed Bipolar Electrode Based Electrochromic Detector for Detection of Multiple Metabolites (Notre Dame IDEA Center)
Kaiyu Fu Receives ACS Division of Analytical Chemistry Summer Graduate Student Fellowship (Notre Dame Chemistry)
ADV. FUNCT. MATER., 2023, 33, 1, 2208534
In this article, we report an electrochemical biosensor to distinguish molecules with a minuscule difference in chemical composition by tuning the charge state of the surface on which the aptamer probes are immobilized. As an exemplar, it is shown that the strategy can distinguish between doxorubicin and many structurally similar analytes, including its primary metabolite, doxorubicin, which only differs by a single hydroxyl group.
AcS NANO, 2022, 16, 7, 10219-10230
Organized assemblies of cells have demonstrated promise as bioinspired actuators and devices. In this article, we develop a strategy for the rapid formation of functional biorobots composed of live cardiomyocytes. These biorobots can perform actuation functions both through naturally occurring contraction–relaxation cycles and through external control with chemical and electrical stimuli.
Acc. Chem. Res., 2020, 53, 4, 719–728
Nanopore electrode arrays have emerged as powerful tools to investigate electrochemistry at the single-entity level. In this review, we discuss their use to achieve gating of transport, permselectivity, electrochemical zero-mode waveguides for spectroelectrochemistry, and enhanced electrochemical processing.
Small, 2020, 16, 49, 2005185
In this article, we present living immunocyte templated micromotors that demonstrate significantly increased surface interactions and efficient removal of various targets across multiple scales, from ions to cells, compared to smooth synthetic material templated micromotors with the same size and surface chemistry.